The researchers found that, in general, these drugs and other drugs known as nonsteroidal antiinflammatory drugs (NSAIDs) would increase the risk of heart attack by 20% to 50% compared to those who did not use them.
However, for most people, this is only a small increase in the risk - about 1% per year, the researchers said.
However, from a public health point of view, the increase in the risk of heart attack is even small, because the use of non-steroidal anti-inflammatory drugs is very common, "chief researcher Michelle Bally (Michele Bally) said she Is an epidemiologist at the Montreal Hospital Research Center.
Increased risk of heart attack associated with NSAID was observed at any dose of one week, one month, or more than one month. The study found that the risk increased with the dose increase.
NSAIDs are widely used to treat pain and inflammation in long term conditions such as arthritis and other joint disorders. Bally said many people also had short-term problems such as menstrual cramps, colds or flu fever, and occasional back pain or headaches.
She pointed out that the study does not actually prove that NSAIDs cause the possibility of heart attack.
"This is an observational study based on prescription or distribution of drugs, and not all potential influencing factors can be taken into account," Bally said.
"Although this means that the causal relationship can not be concluded, but the study is the largest type of investigation, it is based on real life in the observation.
Taking this into account, Bally and her team expressed the need for careful use of NSAIDS.
To reduce the likelihood of heart injury, she recommends taking into account all available treatment regimens and then deciding to treat occasional pain, fever or inflammation.
Read the NSAID drug label and use the lowest possible effective dose, Bally join Bally, who was studying at the University of Montreal at McGill University.
And the study did not involve a very common, less effective NSAID: low-dose aspirin. Numerous well-designed trials have found that daily "baby aspirin" can help contain the possibility of dangerous people on dangerous heart events.
For the study, Bally and her colleagues analyzed four previously published studies, of which nearly 447,000 were present. More than 61,400 people were suffering from a heart attack.
In this type of study, called meta-analysis, researchers try to find common trends in different studies.
Researchers studied NSAIDs such as Motrin, Advil, Aleve, Voltaren, Celebrex, and Roixichet (Vioxx). Vioxx was pulled from the US market in 2004 because it increased the risk of heart attack and stroke.
Bally said the risk of heart attack associated with NSAIDs was the highest in the first month of use.
The researchers found that in the first 30 days, the daily dose of more than 1,200 mg (mg) of ibuprofen and more than 750 mg of naproxen was particularly harmful"Using NSAID for more than a month, this high risk does not seem to increase further," Bally said. "But we did not repeat the heart attack."
In general, patients with heart disease or heart risk factors are more likely to develop heart attacks after NSAID use than patients without these risk factors, she said.
Bally said patients should be aware of their own heart disease risk and discuss with their physician the use of NSAID.
"People who take these drugs to treat chronic pain disorders may want to consider whether increasing the therapeutic effect can increase the risk of a heart attack," Bally said.
According to this new study and other tests, California heart experts believe that patients should not ignore these drugs.
"Randomized trials and observations show that the use of NSAIDs increases the risk of heart attacks and other types of cardiovascular events," said Dr. Gregg Fonarow. "He is a professor of cardiology at the University of California, Los Angeles.
Fonarow said: "The absolute risk is very small, but everyone considering the use of these drugs should carefully weigh the benefits of this increase in risk.
